Buy AICAR

AICAR peptide primarily functions by activating AMP-activated protein kinase (AMPK), which plays a crucial role in regulating energy metabolism and enhancing endurance. Studies suggest that it increases the uptake of glucose and fatty acid oxidation, making it beneficial for improving performance and promoting fat loss.

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AICAR Pre-Mixed Pen 50mg
£31.46 – £84.94 Select options This product has multiple variants. The options may be chosen on the product page
AICAR Peptide Vial 50mg
£28.88 – £37.86 Select options This product has multiple variants. The options may be chosen on the product page
AICAR Nasal Spray
£36.88 – £68.76 Select options This product has multiple variants. The options may be chosen on the product page

High Purity AICAR Products

PharmaGrade Store Italy provides a range of AICAR products to meet your needs, based on your research objectives:

AICAR Peptide Vial – AICAR lyophilized peptide, packaged in a glass vial intended for intramuscular injection into the muscles of study participants. Please note you also require bacteriostatic water when reconstituting your peptide.
Available in 50mg peptide vials here.
AICAR Nasal Spray – a pre-mixed, ready to use peptide solution for administration via the nasal cavity. Choose from 15 ml or 30ml nasal sprays here.
AICAR Pre-Mixed Peptide Pen – Pre-mixed pen kits and cartridges come ready to use pre-mixed with AICAR peptide and bacteriostatic water. Buy ACE-031 50 mg Pre-Mixed Pen here.

Buy AICAR for Research Purposes

AICAR peptide is known for its ability to activate AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis. Through this activation, AICAR enhances energy metabolism by increasing glucose uptake and promoting fatty acid oxidation, thereby supporting endurance and stamina. This mechanism makes it a popular choice for athletes seeking to improve performance and promote fat loss [1].

Italy Research suggests AICAR can effectively boost physical endurance and aid in weight management reducing adipose tissue, making it a valuable tool in fitness and health. Its potential benefits extend to enhancing metabolic efficiency and supporting overall energy utilization, contributing to improved athletic outcomes [2].

Benefits of AICAR

Italy Studies and in vitro testing have indicated the following potential benefits of AICAR peptide:

AICAR activates AMPK – AMPK is an enzyme which is crucial for cellular energy regulation [3].
Enhances the metabolism – By increasing glucose uptake AICAR can improve the metabolism.
Improves endurance – by improving metabolic efficiency and energy balance, stamina when undertaking physical activity is enhanced [2].
Promotes fatty oxidisation – the oxidisation of fat along with improved metabolism can result in weight loss [1].

Scientific Research AICAR Peptide Italy

Research surrounding AICAR peptide has primarily focused on its role in activating AMP-activated protein kinase (AMPK), a central regulator of energy homeostasis.

Italy Studies have demonstrated that AICAR enhances energy metabolism by increasing glucose uptake and promoting fatty acid oxidation, which supports endurance and aids in fat loss [1]. Significant research has highlighted AICAR’s potential to improve athletic performance, with findings indicating increased stamina and metabolic efficiency.

Furthermore, notable investigations have also suggested that AICAR can help maintain lean muscle mass while promoting fat reduction, making it a valuable asset in fitness and health [4]. These findings underscore AICAR’s promising applications in enhancing overall athletic outcomes.

Buy AICAR Nasal Spray Italy from PharmaGrade.Store – supplying high purity peptides for research use worldwide.

Frequently Asked Questions about AICAR Peptide Italy

Are there any known side effects from using the AICAR nasal spray?

AICAR, when used as an AMPK activator, can have several side effects. Excessive activation of AMPK, or its activation in inappropriate tissues, may lead to serious issues such as neurodegeneration. Additionally, prolonged use of AICAR has been associated with increased adipose triglyceride lipase content and fatty acid release. There are also reports of serious renal side effects in patients with severe comorbidities. It’s important to approach the use of AICAR with caution and under professional guidance.

Can AICAR help with obesity?

AICAR has shown potential in addressing obesity-related issues. Italy Research indicates that AICAR can significantly suppress adipose inflammation in diet-induced obese mice [5]. It may also promote metabolic health and protect against obesity-induced systemic diseases. Additionally, AICAR has been found to reduce fat content in certain studies. However, these findings are primarily based on animal studies, and more research is needed to fully understand its effects and potential applications in humans [1].

Can AICAR reduce inflammation?

Yes, AICAR has been shown to reduce inflammation, particularly in the context of obesity-induced conditions. Studies have demonstrated that long-term administration of low-dose AICAR can significantly suppress adipose inflammation in diet-induced obese mice. This suggests that AICAR may have anti-inflammatory properties, although further research is needed to confirm its effectiveness and safety in humans.

Blogs:

Understanding Peptides for Metabolism Management

This blog explores MOTS-c peptide and its potential in metabolism management. It highlights MOTS-c as a mitochondrial-derived peptide that plays a significant role in regulating energy expenditure, influencing fat metabolism, and enhancing cellular stress response. The article discusses how MOTS-c, AICAR and IGF-1 LR3 peptides can improve glucose uptake in muscle cells, promote the breakdown of fatty acids, and bolster resilience against oxidative stress, which are crucial for metabolic health.

Discover more about optimising metabolic health here.

Peptides that Change the Game for Fat Loss: Exploring Fat Loss Peptides

This peptide discusses various peptides that are revolutionizing fat loss by mimicking natural body processes like hormone and enzyme signalling. It highlights peptides such as AICAR and CJC-1295 DAC which enhance metabolism and promote fat loss by stimulating growth hormone release and improving energy management. The article also covers appetite-suppressing peptides like Tesofensine, which help reduce food intake and increase energy expenditure.

Explore fat loss boosting peptides in our blog.

Scientific Research:

[1] Yang Z, Wang X, He Y, Qi L, Yu L, Xue B, Shi H. The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1. PLoS One. 2012;7(11):e49935.

[2] Višnjić D, Lalić H, Dembitz V, Tomić B, Smoljo T. AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review. Cells. 2021 May 4;10(5):1095.

[3] Szewczuk M, Boguszewska K, Kaźmierczak-Barańska J, Karwowski BT. The role of AMPK in metabolism and its influence on DNA damage repair. Mol Biol Rep. 2020 Nov;47(11):9075-9086.

[4] ElAzzouny MA, Evans CR, Burant CF, Kennedy RT. Metabolomics Analysis Reveals that AICAR Affects Glycerolipid, Ceramide and Nucleotide Synthesis Pathways in INS-1 Cells. PLoS One. 2015 Jun 24;10(6):e0129029.

[5] Drake JC, Alway SE, Hollander JM, Williamson DL. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signalling and translational capacity in fasted skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1546-54.

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DISCLAIMER: All products sold by PharmaGrade.Store are for research and laboratory use only. These products are not designed for use or consumption by humans or animals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such. By purchasing from our Website the buyer accepts and acknowledges the risks involved with handling of these products. All articles and product information provided on this Website are for informational and educational purposes only. Handling and use of these products should be restricted to suitably qualified professionals